First immunotherapeutic CAR-T cells against the immune checkpoint protein HLA-G
François Anna, Elodie Bole-Richard, Joel LeMaoult, Marie Escande, Martin Lecomte, Jean-Marie Certoux, Philippe Souque, Francine Garnache, Olivier Adotevi, Pierre Langlade-Demoyen, Maria Loustau, Julien Caumartin
Journal for ImmunoTherapy of Cancer, March 2021
Inhibition of iNKT Cells by the HLA-G-ILT2 Checkpoint and Poor Stimulation by HLA-G-Expressing Tolerogenic DC
Ching-Lien Wu, Julien Caumartin, Giada Amodio, François Anna, Maria Loustau, Silvia Gregori, Pierre Langlade-Demoyen, Joel LeMaoult
Frontiers in Immunology, 11 January 2021
HLA-G Neo-Expression on Tumors
Loustau M, Anna F, Dréan R, Lecomte M, Langlade-Demoyen P, Caumartin J.
Frontiers in Immunology 2020
CD28/4-1BB CD123 CAR T cells in blastic plasmacytoid dendritic cell neoplasm
Bôle-Richard E, Fredon M, Biichlé S, Anna F, Certoux J-M, Renosi F, Tsé F, Molimard C, Valmary-Degano S, Jenvrin A, Warda W, Pallandre J-R, BonnefoyF , Poussard M, Deschamps M, Petrella T, Roumier C, Macintyre E, Féger F, Brissot E, Mohty M, HoWangYin K-Y, Langlade-Demoyen P, Loustau M, Caumartin J, Godet Y, Binda D, Pagadoy M, Deconinck E, Daguindau E, Saas P, Ferrand C, Angelot-Delettre F, Adotévi O, Garnache-Ottou F.
Leukemia 2020
A First-in-Human Phase I Study of INVAC-1, an Optimized Human Telomerase DNA Vaccine in Patients with Advanced Solid Tumors
Teixeira L, Medioni J, Garibal J, Adotévi O, Doucet L, Dragon Durey M-A, Ghrieb Z, Kiladjian J-J, Brizard M, Laheurte C, Wehbe M, Pliquet E, Escande E, Defrance R, Culine S, Oudard SM, Wain-Hobson S, Doppler V, Huet T, Langlade-Demoyen P.
Clinical Cancer Research 2019, CCR-19-1614
Heparan Sulfate Proteoglycans Promote Telomerase Internalization and MHC Class II Presentation on Dendritic Cells
Jeanne Galaine, Guillaume Kellermann, Yves Guillaume, Romain Boidot, Emilie Picard, Romain Loyon, Lise Queiroz, Laura Boullerot, Laurent Beziaud, Marine Jary, Laura Mansi, Claire André, Lydie Lethier, Evelyne Ségal-Bendirdjian, Christophe Borg, Yann Godet, Olivier Adotévi
Journal of Immunology, 2019, DOI : 10.4049/jimmunol.1502633
A DNA telomerase vaccine for canine cancer immunotherapy
Thalmensi J, Pliquet E, Liard C, Chamel G, Kreuz C, Bestetti T, Escande M, Kostrzac A, Pailhes-Jimenez AS, Bourges E, Julithe M, Bourre L, Keravel O, Clayette P, Huet T, Wain-Hobson S, Langlade-Demoyen P.
Oncotarget 2019; 10:3361-3372
Strong antigen-specific T-cell immunity induced by a recombinant human TERT measles virus vaccine and amplified by a DNA/viral vector prime boost in IFNAR/CD46 mice.
Pliquet E, Ruffie C, Escande M, Thalmensi J, Najburg V, Combredet C, Bestetti T, Julithe M, Liard C, Huet T, Wain-Hobson S, Tanguy F, Langlade-Demoyen P.
Anti-cancer DNA vaccine based on human telomerase reverse transcriptase generates a strong and specific T cell immune response.
Thalmensi J, Pliquet E, Liard C, Escande M, Bestetti T, Julithe M et al. OncoImmunology.
Optimization of a gene electrotransfer procedure for efficient intradermal immunization with an hTERT-based DNA vaccine in mice.
Calvet CY, Thalmensi J, Liard C, Pliquet E, Bestetti T, Huet T, Langlade-Demoyen P, Mir LM.
Mol Ther Methods Clin Dev. 2014 Sep 24;1:14045. doi: 10.1038/mtm.2014.45. eCollection 2014.
APOBEC3A catabolism of electroporated plasmid DNA in mouse muscle.
Kostrzak A, Henry M, Langlade-Demoyen P, Wain-Hobson S, Vartanian JP.
Gene Ther. 2015 Jan;22(1):96-103.
Universal tumor-reactive helper peptides from telomerase as new tools for anticancer vaccination
Magalie Dosset, Charline Vauchy, Laurent Beziaud, Olivier Adotevi, Yann Godet
Oncoimmunology 2013, DOI : 10.4161/onci.23430
Universal cancer peptide-based therapeutic vaccine breaks tolerance against telomerase and eradicates established tumor.
Dosset M, Godet Y, Vauchy C, Beziaud L, Lone YC, Sedlik C, Liard C, Levionnois E, Clerc B, Sandoval F, Daguindau E, Wain-Hobson S, Tartour E, Langlade-Demoyen P, Borg C, Adotévi O.
Clin Cancer Res. 2012 Nov 15;18(22):6284-95.
Analysis of spontaneous tumor-specific CD4 T-cell immunity in lung cancer using promiscuous HLA-DR telomerase-derived epitopes: potential synergistic effect with chemotherapy response.
Godet Y, Fabre E, Dosset M, Lamuraglia M, Levionnois E, Ravel P, Benhamouda N, Cazes A, Le Pimpec-Barthes F, Gaugler B, Langlade-Demoyen P, Pivot X, Saas P, Maillère B, Tartour E, Borg C, Adotévi O.
Clin Cancer Res. 2012 May 15;18(10):2943-53.
Immunogenicity of a recombinant lentiviral vector carrying human telomerase tumor antigen in HLA-B*0702 transgenic mice.
Rusakiewicz S, Dosset M, Mollier K, Souque P, Charneau P, Wain-Hobson S, Langlade-Demoyen P, Adotévi O.
Vaccine. 2010 Aug 31;28(38):6374-81.
Targeting human telomerase reverse transcriptase with recombinant lentivector is highly effective to stimulate antitumor CD8 T-cell immunity in vivo.
Adotévi O, Mollier K, Neuveut C, Dosset M, Ravel P, Fridman WH, Tartour E, Charneau P, Wain-Hobson S, Langlade-Demoyen P.
Blood. 2010 Apr 15;115(15):3025-32.
